The influence of the metabolic activity of the intestinal microflora on the severity and duration of rotavirus diarrhea in early-aged children

The aim is to determine the pathogenetic role of metabolic activity intestinal microflora in formation severity and duration rotavirus diarrhea early-aged children. Materials methods. 60 children aged 1–24 months with RVI were included research group. was determined by detecting short-chain fatty acids (SCFAs) feces dynamics disease (the absolute concentration (μmol/l) acetate, propionate, butyrate, total SCFAs value anaerobic index (AI) on 3rd, 5th 10th days RVI) using high-performance liquid chromatography LC-MS Agilent 1260 Infinity HPLC System, USA. Results. From day RVI, a minimally expressed diarrheal syndrome, higher pool SCFA AI values observed than moderate-severe severe (p ˂ 0.05 RVI). A longer syndrome associated decrease sucrolytic bacteria: patients ≤5 had 2.4 times indicators SCFA, ≥6 0.05). degree reduction C3 2–3rd directly correlated diarrhea, which increased 1 20.6 μmol/l or 0.05. Conclusions. influence deficiency manifests itself from illness. propionate earliest indicator prolonged RVI.